Organic sulphur is a crucial way to deliver sulphur to our cells, which in turn, delivers some stunning health benefits. Many of its medical properties were discovered in by a research team headed by Stanley W.
Jacob, MD. Every living cell, plant or animal, contains sulphur. Given that the human body is a collection of trillions and trillions of cells, if we want to have a happy body — we first have to have happy cells. Since organic sulphur plays an essential role in the oxygenation and detoxification of all living things….. As a Naturopathic Nutritionist, I would prefer to get what I need to keep me well by eating real food, including high sulphur foods, such as:.
Fish, grass-fed beef, free-range poultry, nuts, legumes, eggs and Cruciferous Vegetables Watercress, broccoli, cauliflower, cabbage, kale, Brussels sprouts, turnips, bok choy. A generation ago, we switched from manure as a fertiliser to chemical based fertilisers…..
We now know that this has created one of the biggest global deficiencies ever known — a sulphur deficiency. Supplementing with organic sulphur is not only a good idea….. Both DMSO and MSM contain organic sulphur molecules — in recent years, MSM has become one of the hottest selling nutritional supplements as swarms of people with health problems report fantastic results, some that borderline on the miraculous.
There are literally thousands of documents relating to the efficacy of organic sulphur……the list of benefits is longer than an orangutans arm. Take a look at the list below — these are just some of the conditions it can help — it gives you a clue as to how powerful it is. There is no other mineral or nutrient that works as well for protecting, building and restoring health…..
Since this article is specifically about pain and natural alternatives to pain management — we have to firstly acknowledge pain is a symptom of another problem. The temple of ALL disease is held up because cells are full of toxins waste that the cells cannot get rid of.
A toxic cell is also a cell that cannot fully repair itself. Leaving it undernourshed, lacking the materials urgently needed to repair itself — leaving us sick and tired. Organic sulphur demolishes the temple of disease by detoxifying cells including heavy metals and waste molecules built up over decades of poor living.
Indeed, recently, methylation changes of repetitive sequences, in particular satellite repeat elements, have been found in cardiomyopathic heart tissue compared to normal heart tissue Furthermore, it is also possible that DMSO acts as a methyl donor to induce hypermethylation However, it has to be kept in mind that there is an interplay between DNA methylation and chromatin configuration, which is regulated by more processes than just DNMTs.
Overall, we speculate the effects of DMSO on methylation changes to be a global deregulation characterized by a genome wide hypermethylation. Cell mechanisms in charge of removing detrimental methylations at important regions, such as TFBS, may then have removed the methylation changes with a negative outcome on cell survival, leaving an over-representation of DMR in the repetitive elements.
This is in analogy to mutation rates, which are higher for repetitive elements since they are less subjected to natural selection and DNA repair mechanisms We believe that the methylation difference between mature hepatic and maturing cardiac cells may be detrimental for cryopreserved cells and especially for oocytes and embryos.
Previously reported DMSO effects on oocytes and embryos are limited to changes in gene expression in animal models 27 , 33 , 34 , 35 , We now showed, for the first time, the influence of DMSO on the epigenome of human cells in vitro. It is uncertain if exposed cells can recover from temporary DMSO exposures.
While methylation changes have an adaptive nature, they may also be persistent. From research conducted on the Dutch famine cohort, it is known that the periconceptional period before conception until early pregnancy is crucial for establishing and maintaining epigenetic marks. During this period epigenetic marks present on the parental DNA are removed to produce a totipotent zygote which is reprogrammed after implantation Exposures during this time may induce persistent epigenetic differences, which can result in disease later in life or possibly be inherited by the offspring to induce transgenerational effects 38 , 39 , 40 , 41 , It is already well known that infants conceived through assisted reproductive technologies are prone to be born preterm, have low birth weight and even have a significantly increased risk of birth defects 43 , Furthermore, some short-term health outcomes were slightly poorer in children conceived by IVF, though overall the outcomes were positive 42 , Regarding long-term health and development, though available data is limited, cardiovascular and metabolic risk factors that may ultimately result in chronic cardiometabolic disease have been indicated Furthermore, also epigenetic risks have been debated, mostly focusing on methylation and imprinting.
For the most studied imprinting disorders Beck-with-Wiedemann syndrome and Angelman syndrome, the incidence was higher for children born after assisted reproductive technologies compared to natural conception 41 , 46 , 47 , 48 , 49 , While there are many factors contributing to these abnormalities, decreased infertility, higher age of the parents, technical interference with a biological process, etc.
DMSO-induced effects may be one of them. In the last decade, improvements made in artificial reproductive technology greatly increased the success rate of IVF treatments. Especially, improved cryopreservation techniques transition to vitrification aided greatly.
Though not proven yet, increased success rates are reported when implanting previously frozen embryos 51 , 52 , Furthermore, while storing frozen oocytes was initially intended for women threatened by decreased fertility due to disease, in our carrier-focused society, it has also become a method to prevent age-related infertility for women who want to delay motherhood The most recent development in assisted reproductive technology is the emerging of concerns about DMSO effects.
While there is still controversy on this topic, the field is moving towards DMSO-free methods. However, DMSO-free does not automatically mean safe because of the use of other cryoprotectants 55 , 56 , Our study highlights the capability of DMSO to induce changes in cellular processes in both cardiac and hepatic cells, but more severely, induce alterations in miRNA and epigenetic landscape in the 3D maturing cardiac model.
The changes in cellular processes can have consequences for conclusions drawn from cell assays and therefore also in any application of these findings e.
Furthermore, the extreme changes in miRNA and alterations in the epigenetic landscape may pose a threat, especially for assisted reproductive technology. Genome-wide hypermethylation induced by global deregulation of methylation mechanisms, especially when it affects genes important in development, may have negative consequences directly, later in life or possibly in later generations.
Overall, use of DMSO should be avoided where possible. However, for the time being, DMSO is indispensable within biotechnological applications. In these cases, the effects that DMSO may have should be considered and the concentration should be kept as low as possible, because even at low concentrations DMSO is not inert. In this study, 3D InSight TM Human Cardiac Microtissues InSphero, for beta-testers were used, containing a co-culture of approximately iPSC-derived human cardiomyocytes from a female Caucasian donor with no known disease phenotype and cardiac fibroblasts from an 18 year old Caucasian male.
Furthermore, 3D InSight TM Human Liver Microtissues InSphero were used, approximately primary human hepatocytes multi-donor pool of 5 males and 5 females between 7—59 years old in co-culture with primary human Kupffer cells from a Caucasian 27 year old of unreported gender. Medium was changed three times daily, in concordance with the experimental design of our current research Two files per sample were obtained, split in left and right reads, and Lexogen adapter sequences first 12 bases of all reads were removed using Trimmomatic 59 v.
The quality of the sequencing data was checked using FastQC 60 v. For cardiac samples, no samples were discarded because of poor quality.
For hepatic samples, no samples were discarded. Here, the design was set according to exposure UNTR or DMSO , other settings were kept to their default parameters, except for minimum count, which was set to an average read count of one across all samples. Finally, remaining ribosomal genes were filtered out of the dataset to ensure complete ribosomal depletion of the data.
Furthermore, principal component analysis Supplementary Fig. MiRNA data analysis was done similarly as described previously 65 , except for the use of mirDeep2, which does not gain additional information when using human samples.
In short, PatMaN 66 v. Proteomics data was also obtained and analyzed. Methods and results are included in Supplementary data. Because of lower DNA yield for cardiac 0. In short, denatured DNA was mixed with antimeC-antibody and captured using magnetic beads. In order to gain exhaustive genome-wide coverage the triplicate samples that have been sequenced individually were merged before alignment. Galvao, J. Unexpected low-dose toxicity of the universal solvent DMSO.
Sumida, K. Effects of DMSO on gene expression in human and rat hepatocytes. Yuan, Y. Efficient long-term cryopreservation of pluripotent stem cells at degrees C.
Brobyn, R. The human toxicology of dimethyl sulfoxide. Ann N Y Acad Sci , — Rubin, L. Toxicologic update of dimethyl sulfoxide. Ann N Y Acad Sci , 6—10 Smith, E. The single—and repeated—dose toxicity of dimethyl sulfoxide. Ann N Y Acad Sci , 96— Jacob, S. Pharmacology of DMSO. Cryobiology 23 , 14—27 Edgar, D. A critical appraisal of cryopreservation slow cooling versus vitrification of human oocytes and embryos.
Article PubMed Google Scholar. Denko, C. Distribution of dimethyl sulfoxideS in the rat. Ann N Y Acad Sci , 77—84 Yu, Z. Dimethyl sulphoxide: a review of its applications in cell biology. Biosci Rep 14 , — Deng, Z. Topical diclofenac therapy for osteoarthritis: a meta-analysis of randomized controlled trials. Fuller, P. Diclofenac sodium topical solution with dimethyl sulfoxide, a viable alternative to oral nonsteroidal anti-inflammatories in osteoarthritis: review of current evidence.
S Kamburov, A. ConsensusPathDB: toward a more complete picture of cell biology. Fabregat, A. The Reactome pathway Knowledgebase. Lederkremer, G. Glycoprotein folding, quality control and ER-associated degradation. Because it pulls water from tissues, DMSO has a diuretic effect, meaning it makes a horse urinate more. This can help flush toxins from the body more quickly.
With this action in mind, DMSO is often given intravenously in the treatment of cantharidin poisoning blister beetle toxicity , to lessen the effect of the toxin on the kidneys and intestinal tract.
After episodes of tying up, DMSO may help horses eliminate waste products of muscle breakdown through their urine more quickly. The diuretic action of DMSO, however, can make it unsafe for horses who are dehydrated or in shock. It can further dehydrate these animals or dangerously lower their blood pressure. For instance, treating rainrot or other skin infections can be difficult because the responsible organisms are buried deep under the skin or crusty, painful scabs.
However, a mixture combining antibacterial medication with DMSO can pass through the skin and reach the affected area. For the same reason, DMSO is often added to antifungal medications for treatment of eye conditions and sometimes to steroids for targeted, topical anti-inflammatory treatment. Likewise, avoid mixing DMSO with substances that could be toxic if ingested, such as organophosphates or mercury salt.
Research shows that DMSO slows or blocks conduction of impulses along nerve cells, which in effect reduces pain from musculoskeletal injuries, postoperative incisions and other sources. Relief is only temporary—lasting up to a few hours—because as the DMSO dissipates, normal nerve function returns.
It can be combined with other pain-relieving drugs, however, to extend the analgesic action. Some applications of DMSO combine all of these: For instance, it is often used in surgical colic cases to reduce the risk of tissue adhesions due to inflammation and poor circulation; some surgeons think that it may also provide some pain relief in the hours following surgery. The Jockey Club allows 10 micrograms per milliliter of plasma. If you compete with your horse, check any governing association rules regarding DMSO use.
Also keep in mind that because DMSO can move other materials through the skin, combining it with other medications could result in a violation of thresholds for both. A search of a research database will turn up a good sampling of peer-reviewed papers on DMSO use in horses, but the compound has gotten far less scientific scrutiny than have medications developed specifically for therapeutic applications. Scant information is available regarding dosing.
Often veterinarians rely on their own experiences and those of their colleagues in deciding when and how to use DMSO. Whether applied topically, orally, intravenously or by injection, DMSO requires careful handling. This by-product of the paper making process was discovered in Germany in the late 19th century. Scientists discovered that they could use DMSO as a transportation device to pass small molecules through skin.
Since then, scientists have researched the potential benefits and risks of using DMSO to treat a variety of conditions. This research is ongoing.
Some doctors began to use DMSO to treat cases of skin inflammation and diseases such as scleroderma because of its ability to penetrate skin. Scleroderma is a rare disorder that causes your skin to harden. Specifically, DMSO may help treat chemotherapy extravasations. This condition occurs when the drugs used to treat cancer leak and become trapped in surrounding tissues. It can cause symptoms that include:.
However, more research is needed to assess the potential benefits and risks of using DMSO to treat these conditions. This is a chronic condition that causes inflammation in your bladder. To treat it, your doctor may flush DMSO into your bladder using a catheter over several of weeks. While DMSO has been approved for a variety of uses in dogs and horses, interstitial cystitis remains its only FDA-approved use in humans. The use of DMSO in animals has been linked to changes to their eye lenses.
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